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dc.contributor.authorCorrales, Alfonsoes_ES
dc.contributor.authorDessein, Patrick Hes_ES
dc.contributor.authorTsang, Lindaes_ES
dc.contributor.authorPina Murcia, Trinitarioes_ES
dc.contributor.authorBlanco Alonso, Ricardoes_ES
dc.contributor.authorGonzález Juanatey, Carloses_ES
dc.contributor.authorLlorca Díaz, Francisco Javier es_ES
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel es_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractINTRODUCTION: We previously reported that most patients with rheumatoid arthritis (RA) and moderate cardiovascular disease (CVD) risk according to the Systematic COronary Evaluation score (SCORE) experience carotid artery plaque. In this study, we aimed to identify patient characteristics that can potentially predict carotid plaque presence in women with RA and a concurrent low CVD risk according to the SCORE. METHODS: A cohort of 144 women with an evaluated low risk of CVD (SCORE value of zero) was assembled amongst 550 consecutive patients with RA that underwent CVD risk factor recording and carotid artery ultrasound. Participants had no established CVD, moderate or severe chronic kidney disease, or diabetes. We assessed carotid plaque(s) presence and its associated patient characteristics. RESULTS: Carotid artery plaque was present in 35 (24.3%) of women with RA. Age, the number of synthetic disease-modifying agents (DMARDs) and total cholesterol concentrations were independently associated with plaque in multivariable stepwise backward regression analysis (odds ratio (95% confidence interval)=1.15 (1.07 to 1.24), P<0.0001, 1.51 (1.05 to 2.17), P=0.03 and 1.66 (1.00 to 2.73) P=0.04), respectively). The area under the curve (AUC) of the receiver operating curve (ROC) for the association with plaque was 0.807 (P<0.0001), 0.679 (P=0.001) and 0.599 (P=0.08) for age, total cholesterol concentrations and number of synthetic DMARDs used, respectively. The optimal cutoff value in predicting plaque presence for age was 49.5 years with a sensitivity and specificity of 74% and 75%, respectively, and for total cholesterol concentration, it was 5.4 mmol/l with a sensitivity and specificity of 63% and 70%, respectively. The plaque prevalence was 37.5% in patients (n=80; 55.6%) with age>49.5 years or/and total cholesterol concentration of >5.4 mmol/l, respectively, compared to only 7.8% in those (n=64; 44.4%) with age≤49.5 years or/and total cholesterol concentration of ≤5.4 mmol/l, respectively. CONCLUSIONS: Approximately one-third of women with RA who experience a low SCORE value and are aged >49.5 years or/and have a total cholesterol concentration of >5.4 mmol/l, experience high-risk atherosclerosis, which requires intensive CVD risk management.es_ES
dc.format.extent8 p.es_ES
dc.rightsAtribución 3.0 España*
dc.sourceArthritis research & therapy 2015 Mar 11;17:55es_ES
dc.titleCarotid artery plaque in women with rheumatoid arthritis and low estimated cardiovascular disease risk: a cross-sectional studyes_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España