Carbon nanotube coated particles (CCP) for cytoplasmic delivery system
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AuthorIturrioz Rodríguez, Nerea
During years, different delivery strategies have been used such as viral and non-viral or synthetic vectors. The viral vectors have the advantage that can do a specific receptor-mediated endocytosis and escape lysosomes once are inside cells. But they can cause an immune response, provoke insertional mutagenesis and cannot deliver therapeutic proteins. Synthetic vector such as exosomes or lysosomes, don’t cause immune response and can introduce proteins, but their entry mechanism is no so specific and the efficiency to integrate the cargo is lower. In the view of this, we have investigated the biosynthetic interaction of a new carbon nanotube-coated particle (CCP) for cytoplasmic cargo delivery.