Multiwalled carbon nanotubes hinder microglia function interfering with cell migration and phagocytosis

Villegas Sordo, Juan Carlos; Álvarez-Montes, Laura; Rodríguez-Fernández, Lidia; González Gómez, Jesús Antonio; Valiente Barroso, Rafael; López Fanarraga, Mónica

doi:10.1002/adhm.201300178

View/Open

MultiwalledCarbonNan ... (1.417Mb)

Identificadores

URI: http://hdl.handle.net/10902/7992

DOI: 10.1002/adhm.201300178

ISSN: 2192-2640

ISSN: 2192-2659

Date

2014-03

Derechos

This is the peer reviewed version of the following article: “Multiwalled carbon nanotubes hinder microglia function interfering with cell migration and phagocytosis”, which has been published in final form at 10.1002/adhm.201300178. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

Publicado en

Adv Healthc Mater. 2014 Mar;3(3):424-32

Publisher

Wiley-VCH Verlag

Palabras clave

Apoptosis

Carbon nanotubes

Migration

Phagocytosis

Proliferation

Abstract:

The intranasal drug delivery route provides exciting expectations regarding the application of engineered nanomaterials as nano-medicines or drug-delivery vectors into the brain. Among nanomaterials, multiwalled CNTs (MWCNTs) are some of the best candidates for brain cancer therapy since they are well known to go across cellular barriers and display an intrinsic ability to block cancer cell proliferation triggering apoptosis. This study reveals that microglial cells, the brain macrophages and putative vehicles for MWCNTs into the brain, undergo a dose-dependent cell division arrest and apoptosis when treated with MWCNTs. Moreover, it is shown that MWCNTs severely interfere with both cell migration and phagocytosis in live microglia. These results lead to a re-evaluation of the safety of inhaled airborne CNTs and provide strategic clues of how to biocompatibilize MWCNTs to reduce brain macrophage damage and to develop new nanodrugs.