Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes
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AuthorGarcía Hevia, Lorena; Valiente Barroso, Rafael; Fernández Luna, José Luis; Flahaut, Emanuel; Rodríguez Fernández, Lidia; Villegas Sordo, Juan Carlos; González Gómez, Jesús Antonio; López Fanarraga, Mónica
Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.