OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain
View/ Open
Full record
Show full item recordAuthor
Cayô da Silva, Rodrigo; Merino Carballeira, María; Ruiz del Castillo, Belén; Cano García, María Eliecer; Calvo Montes, Jorge; Bou Arévalo, Germán; Martínez Martínez, Luis
Date
2014-08Derechos
© American Society for Microbiology
Publicado en
Antimicrobial Agents and Chemotherapy. 2014 Aug;58(8):4944-8
Publisher
American Society for Microbiology
Abstract:
A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.
Collections to which it belong
- D02 Artículos [296]
- IDIVAL Artículos [540]