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    OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain

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    URI: http://hdl.handle.net/10902/7262
    DOI: 10.1128/AAC.02633-13
    ISSN: 0066-4804
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    Author
    Cayô da Silva, Rodrigo; Merino Carballeira, María; Ruiz del Castillo, Belén; Cano García, María Eliecer; Calvo Montes, Jorge; Bou Arévalo, Germán; Martínez Martínez, LuisAutoridad Unican
    Date
    2014-08
    Derechos
    © American Society for Microbiology
    Publicado en
    Antimicrobial Agents and Chemotherapy. 2014 Aug;58(8):4944-8
    Publisher
    American Society for Microbiology
    Abstract:
    A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.
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    • D02 Artículos [275]
    • IDIVAL Artículos [463]

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    UNIVERSIDAD DE CANTABRIA

    Repositorio realizado por la Biblioteca Universitaria utilizando DSpace software
    Contact Us | Send Feedback
    Metadatos sujetos a:licencia de Creative Commons Reconocimiento 3.0 España