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dc.contributor.authorHorvath, Steve
dc.contributor.authorMah, Vei
dc.contributor.authorLu, Ake T.
dc.contributor.authorWoo, Jennifer S.
dc.contributor.authorChoi, Oi‐Wa
dc.contributor.authorJasinska, Anna J.
dc.contributor.authorRiancho Moral, José Antonio 
dc.contributor.authorTung, Spencer
dc.contributor.authorColes, Natalie S.
dc.contributor.authorBraun, Jonathan
dc.contributor.authorVinters, Harry V.
dc.contributor.authorColes, L. Stephen
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractStudies that elucidate why some human tissues age faster than others may shed light on how we age, and ultimately suggest what interventions may be possible. Here we utilize a recent biomarker of aging (referred to as epigenetic clock) to assess the epigenetic ages of up to 30 anatomic sites from supercentenarians (subjects who reached an age of 110 or older) and younger subjects. Using three novel and three published human DNA methylation data sets, we demonstrate that the cerebellum ages more slowly than other parts of the human body. We used both transcriptional data and genetic data to elucidate molecular mechanisms which may explain this finding. The two largest superfamilies of helicases (SF1 and SF2) are significantly over-represented (p=9.2x10-9) among gene transcripts that are over-expressed in the cerebellum compared to other brain regions from the same subject. Furthermore, SNPs that are associated with epigenetic age acceleration in the cerebellum tend to be located near genes from helicase superfamilies SF1 and SF2 (enrichment p=5.8x10-3). Our genetic and transcriptional studies of epigenetic age acceleration support the hypothesis that the slow aging rate of the cerebellum is due to processes that involve RNA helicases.es_ES
dc.format.extent13 p.es_ES
dc.publisherImpact Journalses_ES
dc.rightsAtribución 3.0 España*
dc.sourceAging (Albany NY). 2015 May 11es_ES
dc.subject.otherBiomarker of aginges_ES
dc.subject.otherTissue aginges_ES
dc.titleThe cerebellum ages slowly according to the epigenetic clockes_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España