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dc.contributor.authorLópez Mejías, Raquel
dc.contributor.authorGenre, Fernanda
dc.contributor.authorSevilla Pérez, Belén
dc.contributor.authorCastañeda Sanz, Santos
dc.contributor.authorOrtego Centeno, Norberto
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.authorUbilla García, Begoña
dc.contributor.authorRemuzgo Martínez, Sara
dc.contributor.authorMijares Díaz, Verónica 
dc.contributor.authorPina Murcia, Trinitario
dc.contributor.authorCalvo Río, Vanesa
dc.contributor.authorMárquez, Ana
dc.contributor.authorMiranda Filloy, José Alberto
dc.contributor.authorNavas Parejo, Antonio
dc.contributor.authorConde Jaldón, Marta
dc.contributor.authorOrtiz Fernández, Lourdes
dc.contributor.authorArgila, Diego
dc.contributor.authorAragües, Maximiliano
dc.contributor.authorRubio Romero, Esteban
dc.contributor.authorLeón Luque, Manuel
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractINTRODUCTION: To determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. METHODS: The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test. RESULTS: A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; p = 0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (p = 0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR = 5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03. Interestingly, the association remained statistically significant (p = 0.0004, OR = 4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found. CONCLUSIONS: Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status.es_ES
dc.format.extent6 p.es_ES
dc.publisherBioMed Centrales_ES
dc.rightsAtribución 3.0 España*
dc.sourceArthritis Research and Therapy. 2015 Apr 14;17(1):102es_ES
dc.titleAssociation of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 statuses_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España