Relationship of sclerostin and secreted frizzled protein polymorphisms with bone mineral density: an association study with replication in postmenopausal women
View/ Open
Full record
Show full item recordAuthor
Valero Díaz de Lamadrid, Carmen



Date
2011-07Derechos
© Lippincott, Williams & Wilkins. This is a non-final version of an article published in final form in Menopause. 2011 Jul;18(7):802-7. doi: 10.1097/gme.0b013e3182091664
Publicado en
Menopause. 2011 Jul;18(7):802-7
Publisher
Lippincott, Williams & Wilkins
Enlace a la publicación
Palabras clave
Osteoporosis
Sclerostin
SOST
FRZB
Association study
Polymorphisms
Abstract:
Objectives.- Secreted frizzled-related protein and sclerostin, encoded by FRZB and SOST genes, respectively, are extracellular Wnt inhibitors that tend to decrease bone formation. The purpose of this study was to explore the association of sets of polymorphisms capturing common variations of these genes with bone mineral density (BMD). Methods.- Twelve polymorphic loci of the FRZB gene and 7 of the SOST gene were genotyped in postmenopausal women from two Spanish regions (Cantabria, n=1043, and Valencia, n=342). The polymorphisms included tagging SNPs and SNPs with possible functional consequences assessed in silico. Results.-The rs4666865 polymorphism of the FRZB gene was associated with spine BMD in the Cantabria cohort in the single-locus (p=0.008) and the haplotypic analysis. However, the results were not replicated in the Valencia cohort. Several polymorphisms at the 5´region of the SOST gene, and particularly rs851056, were associated with BMD in women from both cohorts (p=0.002 in Cantabria and 0.005 in Valencia). When the results of both cohorts were combined, the mean BMD difference across rs851056 genotypes was 47 mg/cm2 or 0.31 standard deviations (p<0.001). No differences in FRZB and SOST expression was detected across genotypes. Conclusions.- Polymorphisms in the 5’ region of SOST gene are associated with BMD in postmenopausal women, and consequently contribute to explain in part the hereditary influence on bone mass.
Collections to which it belong
- D22 Artículos [707]