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dc.contributor.authorRodríguez Rodríguez, Eloy
dc.contributor.authorSánchez Juan, Pascual 
dc.contributor.authorVázquez Higuera, José Luis
dc.contributor.authorMateo Fernández, José Ignacio
dc.contributor.authorPozueta, Ana
dc.contributor.authorBerciano Blanco, José Ángel 
dc.contributor.authorCervantes, Sebastián
dc.contributor.authorAlcolea, Daniel
dc.contributor.authorMartínez Lage, P.
dc.contributor.authorClarimón, Jordi
dc.contributor.authorLleó, Alberto
dc.contributor.authorPastor, Pau
dc.contributor.authorCombarros Pascual, Onofre 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2015-04-20T09:10:46Z
dc.date.available2015-04-20T09:10:46Z
dc.date.issued2013-05
dc.identifier.issn0300-9564
dc.identifier.urihttp://hdl.handle.net/10902/6231
dc.description.abstractAside from APOE, the genetic factors that influence in the progression from mild cognitive impairment (MCI) to Alzheimer´s disease (AD) remain largely unknown. We assessed whether a genetic risk score (GRS), based on 8 non-APOE genetic variants previously associated with AD risk in genome-wide association studies, is associated with either risk of conversion or with rapid progression from MCI to AD. Among 288 subjects with MCI, follow-up (mean 26.3 months) identified 118 MCI-converters to AD and 170 MCI-nonconverters. We genotyped ABCA7 rs3764650, BIN1 rs744373, CD2AP rs9296559, CLU rs1113600, CR1 rs1408077, MS4A4E rs670139, MS4A6A rs610932, and PICALM rs3851179. For each subject we calculated a cumulative GRS, defined as the number of risk alleles (range 0-16) with each allele weighted by the AD risk odds ratio. GRS was not associated with risk of conversion from MCI to AD. However, MCI-converters to AD harboring 6 or more risk alleles (second and third GRS tertiles) progressed 2-fold more rapidly to AD when compared with those with less than 6 risk alleles (first GRS tertile). Our GRS is a first step toward development of prediction models for conversion from MCI to AD that incorporate aggregate genetic factors.es_ES
dc.format.extent19 p.es_ES
dc.language.isoenges_ES
dc.publisherSpringer Verlages_ES
dc.rights© Springer Verlag. The final publication is available at Springer via http://dx.doi.org/10.1007/s00702-012-0920-xes_ES
dc.sourceJournal of Neural Transmission. 2013 May;120(5):807-12es_ES
dc.subject.otherMild cognitive impairmentes_ES
dc.subject.otherAlzheimer's diseasees_ES
dc.subject.otherConversiones_ES
dc.subject.otherGeneticses_ES
dc.subject.otherRiskes_ES
dc.subject.otherGenetic Risk Scorees_ES
dc.titleGenetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttp://link.springer.com/article/10.1007%2Fs00702-012-0920-xes_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1007/s00702-012-0920-x
dc.type.versionacceptedVersiones_ES


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