Bone turnover markers in Spanish adult men The Camargo Cohort Study
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AuthorOlmos Martínez, José Manuel; Hernández Hernández, José Luis; Martínez, Josefina; Pariente Rodrigo, Emilio Jesús; Llorca Díaz, Francisco Javier; González Macías, Jesús
BACKGROUND. This cross-sectional study was performed to determine the
reference ranges for two bone turnover markers -aminoterminal propeptide of
type I collagen (P1NP) and C-terminal telopeptide of type I collagen (-CTX)- in
normal adult Spanish men as measured in serum by automated methods.
METHODS. A community-based population of 660 healthy men ≥ 50 years was
evaluated. Fasting serum levels of P1NP, -CTX, 25-hydroxivitamin D, and
intact parathyroid hormone were measured on the Elecsys 2010 automated
analyzer (Roche). BMD at lumbar spine, femoral neck and total hip was
determined by DXA.
RESULTS. Mean age of participants was 65±9 yrs. Logarithmic transformation
of both markers was performed to allow for normal distribution. Mid-95% ranges
for P1NP and -CTX were 15-78 ng/ml and 0.069-0.760 ng/ml, respectively.
Median and interquartile range of serum P1NP and -CTX were 33.5 [25.5;44.4]
ng/ml and 0.27 [0.19;0.38] ng/ml, respectively. Mean values of P1NP
(37.1±16.7 ng/ml) were similar to those previously described. -CTX mean
values (0.300±0.171 ng/ml) were also similar to those quoted by the
manufacturers in men younger than 70 yrs, but slightly lower than those
reported in subjects older than 70 yrs. Both markers were higher among
osteoporotic men. After excluding from the analysis those men who were found
to have BMD below -2.5 T-score, 25OHD serum level below 30 ng/ml or serum
PTH above 65 pg/ml, P1NP and -CTX ranges were 17-71 ng/ml and 0.070-
0.681 ng/ml, again respectively.
CONCLUSIONS. Values obtained from this well-characterized population study
provide reference ranges for serum automated P1NP and -CTX in normal
Spanish adult men.
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