Time course of bone loss in patients with anorexia nervosa

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URI: http://hdl.handle.net/10902/6223
ISSN: 0276-3478
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Author
Olmos Martínez, José ManuelAutoridad Unican; Valero Díaz de Lamadrid, CarmenAutoridad Unican; Gómez del Barrio, José AndrésAutoridad Unican; Amado Señarís, José AntonioAutoridad Unican; Hernández Hernández, José LuisAutoridad Unican; Menéndez Arango, José; González Macías, JesúsAutoridad Unican
Date
2010-09
Derechos
© Wiley. This is the accepted version of the following article: Olmos, J. M., Valero, C., del Barrio, A. G., Amado, J. A., Hernández, J. L., Menéndez-Arango, J. and González-Macías, J. (2010), Time course of bone loss in patients with anorexia nervosa. Int. J. Eat. Disord., 43: 537–542. doi: 10.1002/eat.20731, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/eat.20731/abstract
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International Journal of Eating Disorders. 2010 Sep;43(6):537-42
Publisher
Wiley
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Palabras clave
Anorexia nervosa
Bone mineral density
Weight recovery
Abstract:
Objective: To evaluate the time course of bone mineral density (BMD) in women with anorexia nervosa (AN) during two years of follow-up. Methods: We prospectively studied 51 female with AN aged 18-38 years, and forty age-matched healthy women (19-34 years). BMD was measured in lumbar spine (LS), femoral neck (FN) and total hip (TH) by DXA. Results: At baseline, weight, body mass index, and lumbar and hip BMD were significantly (p<0.001) lower in AN patients than in controls. Patients who gain weight showed a significant increase in BMD at FN (+1.6%; p<0.05), and TH (+4.4%; p<0.05) and lower non significant changes in LS (+1.3%). Weight at entry, and percent change of weight were significant determinants (p<0.05) of the variability in percent change of BMD at FN and TH, whereas weight at entry was the main determinant of bone modifications at lumbar spine. Conclusions: Our data emphasize the influence of weight gain in recovery of bone mass in AN patients, especially at the hip.
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