Time course of bone loss in patients with anorexia nervosa
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AuthorOlmos Martínez, José Manuel; Valero Díaz de Lamadrid, Carmen; Gómez del Barrio, José Andrés; Amado Señarís, José Antonio; Hernández Hernández, José Luis; Menéndez Arango, José; González Macías, Jesús
Objective: To evaluate the time course of bone mineral density (BMD) in women
with anorexia nervosa (AN) during two years of follow-up.
Methods: We prospectively studied 51 female with AN aged 18-38 years, and
forty age-matched healthy women (19-34 years). BMD was measured in lumbar
spine (LS), femoral neck (FN) and total hip (TH) by DXA.
Results: At baseline, weight, body mass index, and lumbar and hip BMD were
significantly (p<0.001) lower in AN patients than in controls. Patients who gain
weight showed a significant increase in BMD at FN (+1.6%; p<0.05), and TH
(+4.4%; p<0.05) and lower non significant changes in LS (+1.3%). Weight at
entry, and percent change of weight were significant determinants (p<0.05) of
the variability in percent change of BMD at FN and TH, whereas weight at entry
was the main determinant of bone modifications at lumbar spine.
Conclusions: Our data emphasize the influence of weight gain in recovery of
bone mass in AN patients, especially at the hip.
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