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dc.contributor.authorVaqué Díez, José Pedro
dc.contributor.authorMartínez Magunacelaya, Nerea
dc.contributor.authorVarela Egocheaga, Ignacio 
dc.contributor.authorFernández Fernández, Fidel Ángel 
dc.contributor.authorMayorga Fernández, Marta
dc.contributor.authorDerdak, Sophia
dc.contributor.authorBeltrán, Sergi
dc.contributor.authorMoreno Rodríguez, Thaidy
dc.contributor.authorAlmaraz Pro, Carmen
dc.contributor.authorHeras Castaño, Gonzalo de las
dc.contributor.authorBayés, Mónica
dc.contributor.authorGut, Ivo
dc.contributor.authorCrespo García, Javier 
dc.contributor.authorPiris Pinilla, Miguel Ángel 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2015-04-20T07:53:54Z
dc.date.available2015-04-20T07:53:54Z
dc.date.issued2015-03-16
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10902/6221
dc.description.abstractWe have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overlapping mutational signatures highlighting the degree of heterogeneity between multiple specimens in the same patient. Observations in these cases imply that considering not only the number of mutations but an effective oncogenic combination of mutations can determine the malignant progression of colorectal lesions.es_ES
dc.format.extent12 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourcePLoS One. 2015 Mar 16;10(3):e0119946es_ES
dc.titleColorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimenses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1371/journal.pone.0119946
dc.type.versionpublishedVersiones_ES


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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España