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dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorLabayen, Idoia
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorMoreno Aznar, Luis A.
dc.contributor.authorGonzález-Lamuño Leguina, Domingo 
dc.contributor.authorMartí del Moral, Amelia
dc.contributor.authorNova Rebato, Esther
dc.contributor.authorGarcía Fuentes, Miguel 
dc.contributor.authorRedondo Figuero, Carlos 
dc.contributor.authorMartínez Hernández, Alfredo J.
dc.contributor.authorSjöström, Michael
dc.contributor.authorCastillo Garzón, Manuel J.
dc.contributor.authorAVENA Study Group
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractBackground There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3 and the peroxisome proliferator-activated receptor-γ-2 (PPARγ2) polymorphisms influence the association between low birth weight and blood lipid levels in healthy adolescents aged 13–18.5 years. Methods A cross-sectional study of 502 Spanish adolescents born at term was conducted. Total (TC) and high density lipoprotein cholesterol (HDLc), triglycerides (TG), apolipoprotein (apo) A and B, and lipoprotein(a) [Lp(a)] were measured. Low density lipoprotein cholesterol (LDLc), TC-HDLc, TC/HDLc and apoB/apoA were calculated. Results Low birth weight was associated with higher levels of TC, LDLc, apoB, Lp(a), TC-HDLc, TC/HDLc and apoB/apoA in males with the APOE ε3ε4 genotype, whereas in females, it was associated with lower HDLc and higher TG levels. In males with the APOC3 S1/S2 genotype, low birth weight was associated with lower apoA and higher Lp(a), yet this association was not observed in females. There were no associations between low birth weight and blood lipids in any of the PPARγ2 genotypes. Conclusion The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE ε3/ε4 genotype. These findings suggest that intrauterine environment interact with the genetic background affecting the lipid profile in later life.es_ES
dc.format.extent11 p.es_ES
dc.publisherBioMed Centrales_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.sourceBMC Medical Genetics 2008, 9:98es_ES
dc.titleBirth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Studyes_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España