Predictive model for Photodynamic Therapy with gold nanoparticles as vehicle for the photosensitizer delivery
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Identificadores
URI: http://hdl.handle.net/10902/4688DOI: 10.1117/12.2031959
ISBN: 978-0-8194-9652-2
ISSN: 1996-756X
ISSN: 0277-786X
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2013-05Derechos
© 2013 Society of Photo-Optical Instrumentation Engineers and Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Publicado en
I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, and J. L. Arce-Diego, "Predictive model for Photodynamic Therapy with gold nanoparticles as vehicle for the photosensitizer delivery," in European Conference on Biomedical Optics: Medical Laser Applications and Laser-Tissue Interactions VI, L. Lilge and R. Sroka, eds., Vol. 8803 of Proceedings of OSA Biomedical Optics-SPIE, 88030N, (2013).
Publisher
The Optical Society (OSA)-
SPIE Society of Photo-Optical Instrumentation Engineers
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Palabras clave
Photodynamic Therapy
Gold nanoparticles
Photosensitizer
Basal cell carcinoma
Abstract:
Photodynamic Therapy offers multiple advantages to treat nonmelanoma skin cancer compared to conventional treatment techniques such as surgery, radiotherapy or chemotherapy. Among these advantages are particularly relevant its noninvasive nature, the use of non ionizing radiation and its high selectivity. However the therapeutic efficiency of the current clinical protocol is not complete in all the patients and depends on the type of pathology. Emerging strategies to overcome its current shortcomings include the use of nanostructures that can act as carriers for conventional photosensitizers and improve the treatment selectivity and provide a controlled release of the photoactive agent. In this work, a model for photodynamic therapy combined with gold nanocarriers for a photosensitizer commonly used in dermatology is presented and applied to a basal cell carcinoma in order to predict the cytotoxic agent spatial and temporal evolution.
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- D50 Proyectos de Investigación [338]