Photochemical model of Photodynamic Therapy applied to skin diseases by a topical photosensitizer
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AuthorFanjul Vélez, Félix; Salas García, Irene; Fernández Fernández, Luis Alberto; López-Escobar García-Prendes, María; Buelta Carrillo, Luis; Ortega Quijano, Noé; Arce Diego, José Luis
© 2009 Society of Photo-Optical Instrumentation Engineers and Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
F. Fanjul-Vélez, I. Salas-Garcĺa, L. A. Fernández-Fernández, M. López-Escobar, L. Buelta-Carrillo, N. Ortega-Quijano, and J. L. Arce-Diego, "Photochemical model of Photodynamic Therapy applied to skin diseases by a topical photosensitizer," in European Conference on Biomedical Optics: Therapeutic Laser Applications and Laser-Tissue Interactions IV, R. Sroka and L. Lilge, eds., Vol. 7373 of Proceedings of SPIE-OSA Biomedical 73730S, (2009)
The Optical Society (OSA)-
SPIE Society of Photo-Optical Instrumentation Engineers
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Photodynamic Therapy (PDT) provides a non-invasive, efficient and safe treatment for skin diseases with good cosmetic results. These characteristics make this technique more advantageous than radiotherapy or chemotherapy, which present limitations in a big number of lesions, are painful in many cases and produce non-satisfactory cosmetic results. We present the clinical results obtained at present by this optical technique and a photochemical model of the PDT process applied to the skin by means of a topical photosensitizer, in order to find the optimal PDT parameters. Optical propagation inside the tissue is calculated by means of the three dimensional Beer-Lambert law, due to its facility to be integrated in the differential equations system used to model the photochemical processes involved. With this information it is possible to obtain an initial estimation about the optimal drug dose and the optical power required.