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dc.contributor.authorGenre, Fernanda
dc.contributor.authorLópez Mejías, Raquel
dc.contributor.authorMiranda Filloy, José Alberto
dc.contributor.authorUbilla García, Begoña
dc.contributor.authorCarnero López, Beatriz
dc.contributor.authorBlanco Alonso, Ricardo
dc.contributor.authorPina Murcia, Trinitario
dc.contributor.authorGonzález Juanatey, Carlos
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractAnkylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- α therapy was found to be effective to treat AS patients by suppressing inflammation and also improving endothelial function. Previously, it was demonstrated that a short infusion of anti-TNF- α monoclonal antibodyinfliximab induced a rapid and dramatic reduction in serum insulin levels and insulin resistance along with a rapid improvement of insulin sensitivity in nondiabetic AS patients. The role of adipokines, MeS-related biomarkers and biomarkers of endothelial cell activation and inflammation seem to be relevant in different chronic inflammatory diseases. However, its implication in AS has not been fully established. Therefore, in this review we summarize the recent advances in the study of the involvement of these molecules in CV disease or MeS in AS. The assessment of adipokines and biomarkers of endothelial cell activation and MeS may be of potential relevance in the stratification of the CV risk of patients with AS.es_ES
dc.format.extent12 p.es_ES
dc.publisherHindawi Publishing Corporationes_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.sourceBiomed Research International. 2014;2014:860651. Epub 2014 Mar 18es_ES
dc.titleAdipokines, Biomarkers of Endothelial Activation, and Metabolic Syndrome in Patients with Ankylosing Spondylitises_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España