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dc.contributor.authorFenutría, Rafael
dc.contributor.authorMartínez, Vanesa G.
dc.contributor.authorSimoes, Ines
dc.contributor.authorPostigo Fernández, Jorge 
dc.contributor.authorGil Espinosa, Víctor
dc.contributor.authorMartínez Florensa, Mario
dc.contributor.authorSintes, Jordi
dc.contributor.authorNaves, Rodrigo
dc.contributor.authorCashman, Kevin S.
dc.contributor.authorAlberola Ila, José
dc.contributor.authorRamos Casals, Manel
dc.contributor.authorSoldevila Melgarejo, Gloria
dc.contributor.authorRaman, Chander
dc.contributor.authorMerino Pérez, Jesús 
dc.contributor.authorMerino Pérez, Ramón 
dc.contributor.authorEngel Rocamora, Pablo
dc.contributor.authorLozano Soto, Francisco
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractCD5 is a lymphoid-specific transmembrane glycoprotein constitutively expressed on thymocytes and mature T and B1a lymphocytes. Current data support the view that CD5 is a negative regulator of antigen-specific receptor-mediated signaling in these cells, and that this would likely be achieved through interaction with CD5 ligand/s (CD5L) of still undefined nature expressed on immune or accessory cells. To determine the functional consequence of loss of CD5/CD5L interaction in vivo, a new transgenic mouse line was generated (shCD5EμTg), expressing a circulating soluble form of human CD5 (shCD5) as a decoy to impair membrane-bound CD5 function. These shCD5EμTg mice showed an enhanced response to autologous antigens, as deduced from the presentation of more severe forms of experimentally inducible autoimmune disease (collagen-induced arthritis, CIA; and experimental autoimmune encephalitis, EAE), as well as an increased anti-tumoral response in non-orthotopic cancer models (B16 melanoma). This enhancement of the immune response was in agreement with the finding of significantly reduced proportions of spleen and lymph node Treg cells (CD4+CD25+FoxP3+), and of peritoneal IL-10-producing and CD5+ B cells, as well as an increased proportion of spleen NKT cells in shCD5EμTg mice. Similar changes in lymphocyte subpopulations were observed in wild-type mice following repeated administration of exogenous recombinant shCD5 protein. These data reveal the relevant role played by CD5/CD5L interactions on the homeostasis of some functionally relevant lymphocyte subpopulations and the modulation of immune responses to autologous antigens.es_ES
dc.format.extent15 p.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.sourcePLoS One. 2014 Jan 15;9(1):e84895es_ES
dc.titleTransgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responseses_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España