SMAD3 rs17228212 Gene Polymorphism Is Associated with Reduced Risk to Cerebrovascular Accidents and Subclinical Atherosclerosis in Anti-CCP Negative Spanish Rheumatoid Arthritis Patients
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AuthorGarcía Bermúdez, Mercedes; López Mejías, Raquel; Genre, Fernanda; Castañeda Sanz, Santos; González Juanatey, Carlos; Llorca Díaz, Francisco Javier; Corrales Martínez, Alfonso; Miranda Filloy, José Alberto; Rueda Gotor, Javier; Gómez Vaquero, Carmen; Rodríguez Rodríguez, Luis; Fernández Gutiérrez, Benjamín; Pascual Salcedo, Dora; Balsa Criado, Alejandro; López Longo, Francisco J.; Carreira Delgado, Patricia; Blanco Alonso, Ricardo; González Álvaro, Isidoro; Martín Ibáñez, Javier; [et al.]
Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. Previous genome-wide association studies have described SMAD3 rs17228212 polymorphism as an important signal associated with CV events. The aim of the present study was to evaluate for the first time the relationship between this gene polymorphism and the susceptibility to CV manifestations and its potential association with the presence of subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in patients with RA.