© 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer´s Association. This is an open access article under the CC BY-NC-ND license. La licencia Reconocimiento-NoComercial-Sin ObraDerivadaExcept where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer´s Association. This is an open access article under the CC BY-NC-ND license. La licencia Reconocimiento-NoComercial-Sin ObraDerivada