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dc.contributor.authorSan Segundo, David
dc.contributor.authorGalván-Espinoza, Luis H.
dc.contributor.authorRodrigo Calabia, Emilio 
dc.contributor.authorIrure, Juan
dc.contributor.authorRuiz San Millán, Juan Carlos 
dc.contributor.authorFernández Fresnedo, Gema 
dc.contributor.authorRiesco, Laura
dc.contributor.authorBada, Jairo
dc.contributor.authorBelmar, Lara
dc.contributor.authorLópez Hoyos, Marcos 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractBackground: Regulatory T (Treg) cells play a role in limiting kidney transplant rejection and can potentially promote long-term transplant tolerance. There are no large prospective studies demonstrating the utility of peripheral blood Treg cells as biomarkers for long-term graft outcome in kidney transplantation. The aim of our study was to analyze the influence of the absolute number of peripheral blood Treg cells after transplantation on long-term death-censored graft survival. Methods: We monitored the absolute numbers of Treg cells by flow cytometry in nonfrozen samples of peripheral blood in 133 kidney transplant recipients, who were prospectively followed up to 2 years after transplantation. Death-censored graft survival was determined retrospectively in January 2017. Results: The mean time of clinical follow-up was 7.4 ± 2.9 years and 24.1% patients suffered death-censored graft loss (DCGL). Patients with high Treg cells 1 year after transplantation and above the median value (14.57 cells/mm3), showed better death-censored graft survival (5-year survival, 92.5% vs 81.4%, Log-rank P = .030). One-year Treg cells showed a receiver operating characteristic - area under curve of 63.1% (95% confidence interval, 52.9-73.2%, P = 0.026) for predicting DCGL. After multivariate Cox regression analysis, an increased number of peripheral blood Treg cells was a protective factor for DCGL (hazard ratio, 0.961, 95% confidence interval, 0.924-0.998, P = 0.041), irrespectively of 1-year proteinuria and renal function. Conclusions: Peripheral blood absolute numbers of Treg cells 1 year after kidney transplantation predict a better long-term graft outcome and may be used as prognostic biomarkers.es_ES
dc.format.extent6 p.es_ES
dc.publisherWolters Kluweres_ES
dc.rights© 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.es_ES
dc.sourceTransplant Direct . 2019 Feb 8;5(3):e426es_ES
dc.titleRegulatory T-cell Number in Peripheral Blood at 1 Year Posttransplant as Predictor of Long-term Kidney Graft Survivales_ES

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© 2019 The  Author(s).  Transplantation  Direct.  Published  by  Wolters  Kluwer Health, Inc.Except where otherwise noted, this item's license is described as © 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.