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dc.contributor.authorLópez Mejías, Raquel
dc.contributor.authorCarmona, F. David
dc.contributor.authorGenre, Fernanda
dc.contributor.authorRemuzgo-Martínez, Sara
dc.contributor.authorGonzález-Juanatey, Carlos
dc.contributor.authorCorrales Martínez, Alfonso
dc.contributor.authorVicente, Esther F.
dc.contributor.authorPulito Cueto, Verónica
dc.contributor.authorMiranda-Filloy, José A.
dc.contributor.authorRamírez Huaranga, Marco A.
dc.contributor.authorBlanco Alonso, Ricardo
dc.contributor.authorRobustillo-Villarino, Montserrat
dc.contributor.authorRodríguez-Carrio, Javier
dc.contributor.authorAlperi-López, Mercedes
dc.contributor.authorAlegre-Sancho, Juan J.
dc.contributor.authorMijares Díaz, Verónica 
dc.contributor.authorLera-Gómez, Leticia
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel 
dc.contributor.authorPérez-Pampín, Eva
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2019-10-10T09:18:57Z
dc.date.available2020-03-01T03:45:12Z
dc.date.issued2019-03
dc.identifier.issn2326-5205
dc.identifier.issn2326-5191
dc.identifier.urihttp://hdl.handle.net/10902/16985
dc.description.abstractOBJECTIVE: To investigate the genetic background influencing the development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA). METHODS: We performed a genome-wide association study (GWAS) in which, after quality control and imputation, a total of 6,308,944 polymorphisms across the whole genome were analyzed in 2,989 RA patients of European origin. Data on subclinical atherosclerosis, obtained through assessment of carotid intima-media thickness (CIMT) and presence/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals. RESULTS: A genetic variant of the RARB gene (rs116199914) was associated with CIMT values at the genome-wide level of significance (minor allele [G] ? coefficient 0.142, P = 1.86 × 10-8 ). Interestingly, rs116199914 overlapped with regulatory elements in tissues related to CV pathophysiology and immune cells. In addition, biologic pathway enrichment and predictive protein-protein relationship analyses, including suggestive GWAS signals of potential relevance, revealed a functional enrichment of the collagen biosynthesis network related to the presence/absence of carotid plaques (Gene Ontology no. 0032964; false discovery rate-adjusted P = 4.01 × 10-3 ). Furthermore, our data suggest potential influences of the previously described candidate CV risk loci NFKB1, MSRA, and ZC3HC1 (P = 8.12 × 10-4 , P = 5.94 × 10-4 , and P = 2.46 × 10-4 , respectively). CONCLUSION: The present findings strongly suggest that genetic variation within RARB contributes to the development of subclinical atherosclerosis in patients with RA.es_ES
dc.description.sponsorshipThis study was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060 and PI15/00525) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009 and RD16/0012 (RIER) from ISCIII, and in part by grants from the European IMI BTCure Program. RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, “Investing in your future”) (grant CP16/00033). FDC was supported by the “Ramón y Cajal” programme of the Spanish Ministry of Economy and Competitiveness through the grant RYC-2014-16458. FG is a recipient of a Sara Borrell post-doctoral fellowship from the ISCIII, co-funded by the ESF (grant CD15/00095). SR-M is supported by funds of the RETICS Program (RIER) RD16/0012/0009 (ISCIII, co-funded by ERDF). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). VM is supported by funds of a Miguel Servet type I programme (grant CP16/00033) (ISCIII, co-funded by ERDF).es_ES
dc.format.extent10 p.es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley and Sons Ltdes_ES
dc.rights©John Wiley & Sonses_ES
dc.sourceArthritis Rheumatol. 2019 Mar;71(3):351-360es_ES
dc.titleIdentification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://www.doi.org/10.1002/art.40734es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1002/art.40734
dc.type.versionacceptedVersiones_ES


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