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dc.contributor.authorGómez Pastora, Jenifer 
dc.contributor.authorKarampelas, Ioannis H.
dc.contributor.authorBringas Elizalde, Eugenio 
dc.contributor.authorFurlani, Edward P.
dc.contributor.authorOrtiz Uribe, Inmaculada 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractIn this work, we report a numerical flow-focused study of bead magnetophoresis inside a continuous-flow microchannel in order to provide a detailed analysis of bead motion and its effect on fluid flow. The numerical model involves a Lagrangian approach and predicts the bead separation from blood and their collection into a flowing buffer by the application of a magnetic field generated by a permanent magnet. The following scenarios are modelled: (i) one-way coupling wherein momentum is transferred from the fluid to beads, which are treated as point particles, (ii) two-way coupling wherein the beads are treated as point particles and momentum is transferred from the bead to the fluid and vice versa, and (iii) two-way coupling taking into account the effects of bead volume in fluid displacement. The results indicate that although there is little difference in the bead trajectories for the three scenarios, there is significant variation in the flow fields, especially when high magnetic forces are applied on the beads. Therefore, an accurate full flow-focused model that takes into account the effects of the bead motion and volume on the flow field should be solved when high magnetic forces are employed. Nonetheless, when the beads are subjected to medium or low magnetic forces, computationally inexpensive models can be safely employed to model magnetophoresis.es_ES
dc.description.sponsorshipFinancial support from the Spanish Ministry of Economy and Competitiveness under the projects CTQ2015-72364-EXP and CTQ2015-66078-R (MINECO/FEDER) is gratefully acknowledged. Jenifer Gómez-Pastora also thanks the FPI postgraduate research grant (BES-2013-064415). Edward P. Furlani gratefully acknowledges fnancial support from the U.S. National Science Foundation, through Award CBET-1337860.es_ES
dc.format.extent13 p.es_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.sourceScientific reports, 2019, 9, 7265es_ES
dc.titleNumerical analysis of bead magnetophoresis from flowing blood in a continuous-flow microchannel: implications to the bead-fluid interactionses_ES

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Attribution 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution 4.0 International