Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells
View/ Open
Identificadores
URI: http://hdl.handle.net/10902/15874DOI: 10.1155/2019/7518482
ISSN: 1687-4110
ISSN: 1687-4129
Full record
Show full item recordAuthor
Renero Lecuna, Carlos


Date
2019Derechos
Attribution 4.0 International
Publicado en
Journal of Nanomaterials
Volume 2019, Article ID 7518482
Publisher
Hindawi
Enlace a la publicación
Abstract:
The application of nanomaterials in the fields of medicine and biotechnology is of enormous interest, particularly in the areas where traditional solutions have failed. Unfortunately, there is very little information on how to optimize the preparation of nanomaterials for their use in cell culture and on the effects that these can trigger on standard cellular systems. These data are pivotal in nanobiotechnology for the development of different applications and to evaluate/compare the cytotoxicity among the different nanomaterials or studies. The lack of information drives many laboratories to waste resources performing redundant comparative tests that often lead to partial answers due to differences in (i) the nature of the start-up material, (ii) the preparation, (iii) functionalization, (iv) resuspension, (v) the stability/dose of the nanomaterial, etc. These variations in addition to the different analytical systems contribute to the artefactual interpretation of the effects of nanomaterials and to inconsistent conclusions between different laboratories. Here, we present a brief review of a wide range of nanomaterials (nanotubes, various nanoparticles, graphene oxide, and liposomes) with HeLa cells as a reference cellular system. These human cells, widely used as cellular models for many studies, represent a reference system for comparative studies between different nanomaterials or conditions and, in the last term, between different laboratories.
Collections to which it belong
- D02 Proyectos de Investigación [81]
- D02 Artículos [248]