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dc.contributor.authorGómez Acebo, Inés 
dc.contributor.authorDierssen Sotos, Trinidad 
dc.contributor.authorPedro de Cárdenas, María de 
dc.contributor.authorPérez Gómez, Beatriz
dc.contributor.authorCastaño Vinyals, Gemma
dc.contributor.authorFernández Villa, Tania
dc.contributor.authorPalazuelos Calderón, Camilo
dc.contributor.authorAmiano, Pilar
dc.contributor.authorEtxeberria, Jaione
dc.contributor.authorBenavente, Yolanda
dc.contributor.authorFernández Tardón, Guillermo
dc.contributor.authorSalcedo Bellido, Inmaculada
dc.contributor.authorCapelo, Rocío
dc.contributor.authorPeiró, Rosana
dc.contributor.authorMarcos Gragera, Rafael
dc.contributor.authorHuerta, José M.
dc.contributor.authorTardón, Adonina
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorAlonso Molero, Jessica
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractBACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. METHODS: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression. RESULTS: Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4-49.1) in younger than 45 to 21.1% (18.3-24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (<?45 years old) to 12.4% (?75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4-31.2) in women with acute coronary syndrome, 13.3 (6.2-28.3) in women with strokes and 11.1 (7.8-15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions. CONCLUSIONS: Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.es_ES
dc.description.sponsorshipThis work was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/ 00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10–2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOODCT- 2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo. The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.es_ES
dc.format.extent13 p.es_ES
dc.publisherBioMed Centrales_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.sourceBMC Public Health (2018) 18:1134es_ES
dc.subject.otherCardiovascular Riskes_ES
dc.subject.otherGastrointestinal Bleedinges_ES
dc.subject.otherNon-Steroidal Anti-Inflammatory Drugses_ES
dc.titleEpidemiology of non-steroidal antiinflammatory drugs consumption in Spain. The MCC-Spain studyes_ES

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