Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
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AuthorDierssen Sotos, Trinidad; Palazuelos Calderón, Camilo; Jiménez Moleón, José Juan; Aragonés, Nuria; Altzibar, Jone M.; Castaño Vinyals, Gemma; Martín Sanchez, Vicente; Gómez Acebo, Inés; Guevara, Marcela; Tardón, Adonina; Pérez Gómez, Beatriz; Amiano, Pilar; Moreno, Victor; Molina, Antonio J.; Alonso Molero, Jessica; Moreno Iribas, Conchi; Kogevinas, Manolis; Pollán, Marina; Llorca Díaz, Francisco Javier
Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.
One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression.
Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and >?2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced.
The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
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