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dc.contributor.authorFernández Castro, Mónica
dc.contributor.authorSánchez Piedra, Carlos
dc.contributor.authorAndreu, Jose Luis
dc.contributor.authorMartínez Taboada, Víctor Manuel 
dc.contributor.authorOlivé, Alejandro
dc.contributor.authorRosas, Jose
dc.contributor.authorSJOGRENSER Group
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2019-01-11T19:19:04Z
dc.date.available2019-01-11T19:19:04Z
dc.date.issued2018
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.urihttp://hdl.handle.net/10902/15363
dc.description.abstractIntroduction Primary Sjögren?s syndrome (pSS) is an autoimmune disease, characterized by lymphocytic infiltration of exocrine glands and other organs, resulting in dry eye, dry mouth and extraglandular systemic findings. Objective To explore the association of severe or very severe dry eye with extraocular involvement in patients diagnosed with primary Sjögren?s syndrome. Methods SJOGRENSER registry is a multicenter cross-sectional study of pSS patients. For the construction of our main variable, severe/very severe dry eye, we used those variables that represented a degree 3?4 of severity according to the 2007 Dry Eye Workshop classification. First, bivariate logistic regression models were used to identify the effect of each independent variable on severe/very severe dry eye. Secondly, multivariate analysis using regression model was used to establish the independent effect of patient characteristics. Results Four hundred and thirty-seven patients were included in SJOGRENSER registry; 94% of the patients complained of dry eye and 16% developed corneal ulcer. Schirmer?s test was pathological in 92% of the patients; 378 patients presented severe/very severe dry eye. Inflammatory articular involvement was significantly more frequent in patients with severe/very severe dry eye than in those without severe/very severe dry eye (82.5 vs 69.5%, p = 0,028). Inflammatory joint involvement was associated with severe/very severe dry eye in the multivariate analysis, OR 2.079 (95% CI 1.096?3.941). Conclusion Severe or very severe dry eye is associated with the presence of inflammatory joint involvement in patients with pSS. These results suggest that a directed anamnesis including systemic comorbidities, such as the presence of inflammatory joint involvement or dry mouth in patients with dry eye, would be useful to suspect a pSS.es_ES
dc.format.extent8 p.es_ES
dc.language.isoenges_ES
dc.publisherSpringer internationales_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceRheumatol Int. 2018 Jun; 38(6):1075-1082es_ES
dc.subject.otherDry Eye Syndromeses_ES
dc.subject.otherSjögren’s Syndromees_ES
dc.subject.otherJointses_ES
dc.subject.otherSchirmer’s Testes_ES
dc.titleFactors associated with severe dry eye in primary Sjögren´s syndrome diagnosed patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.1007/s00296-018-4013-5es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1007/s00296-018-4013-5
dc.type.versionpublishedVersiones_ES


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Attribution 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution 4.0 International