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    Biodegradable multi-walled carbon nanotubes trigger anti-tumoral effects

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    BiodegradableMultiWa ... (1.156Mb)
    Identificadores
    URI: http://hdl.handle.net/10902/15275
    DOI: 10.1039/c8nr03036g
    ISSN: 2040-3364
    ISSN: 2040-3372
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    Author
    González Lavado, Eloisa; Iturrioz Rodríguez, Nerea; Padín González, Esperanza; González Gómez, Jesús Antonio; García Hevia, Lorena; Heuts, Jeroen; Pesquera González, Carmen; González Martínez, Fernando; Villegas Sordo, Juan Carlos; Valiente Barroso, Rafael; López Fanarraga, Mónica
    Date
    2018-06
    Derechos
    © Royal Society of Chemistry
    Publicado en
    Nanoscale, 2018, 23(10), 11013-11020
    Publisher
    Royal Society of Chemistry
    Disponible después de
    2019-06-01
    Enlace a la publicación
    https://doi.org/10.1039/c8nr03036g
    Abstract:
    Carbon nanotubes are of huge biotechnological interest because they can penetrate most biological barriers and, inside cells, can biomimetically interact with the cytoskeletal filaments, triggering anti-proliferative and cytotoxic effects in highly dividing cells. Unfortunately, their intrinsic properties and bio-persistence represent a putative hazard that relapses their application as therapies against cancer. Here we investigate mild oxidation treatments to improve the intracellular enzymatic digestion of MWCNTs, but preserving their morphology, responsible for their intrinsic cytotoxic properties. Cell imaging techniques and confocal Raman spectroscopic signature analysis revealed that cultured macrophages can degrade bundles of oxidized MWCNTs (o-MWCNTs) in a few days. The isolation of nanotubes from these phagocytes 96 hours after exposure confirmed a significant reduction of approximately 30% in the total length of these filaments compared to the control o-MWCNTs extracted from the cell culture medium, or the intracellular pristine MWCNTs. More interestingly, in vivo single intratumoral injections of o-MWCNTs triggered ca. 30% solid melanoma tumour growth-inhibitory effects while displaying significant signs of biodegradation at the tumoral/peri-tumoral tissues a week after the therapy has had the effect. These results support the potential use of o-MWCNTs as antitumoral agents and reveal interesting clues of how to enhance the efficient clearance of in vivo carbon nanotubes.
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    UNIVERSIDAD DE CANTABRIA

    Repositorio realizado por la Biblioteca Universitaria utilizando DSpace software
    Contact Us | Send Feedback
    Metadatos sujetos a:licencia de Creative Commons Reconocimiento 3.0 España