Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks
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AuthorFrancisco, Vera; Pérez, Tamara; Pino, Jesús; López, Verónica; Franco, Eloy; Alonso, Ana; González-Gay Mantecón, Miguel Ángel; Mera, Antonio; Lago, Francisca; Gómez, Rodolfo; Gualillo, Oreste
© Orthopaedic Research Society. Published by Wiley. This is the peer reviewed version of the following article: Francisco, Vera, et al. «Biomechanics, Obesity, and Osteoarthritis. The Role of Adipokines: When the Levee Breaks: ADIPOKINES IN BIOMECHANICS, OBESITY, AND OSTEOARTHRITIS». J Orthop Res. 2018 Feb;36(2):594-604, which has been published in final form at https://dx.doi.org/10.1002/jor.23788. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
J Orthop Res. 2018 Feb;36(2):594-604
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Osteoarthritis is a high-incidence painful and debilitating disease characterized by progressive degeneration of articular joints, which indicates a breakdown in joint homeostasis favoring catabolic processes. Biomechanical loading, associated with inflammatory and metabolic imbalances of joint, strongly contributes to the initiation and progression of the disease. Obesity is a primary risk factor for disease onset, and mechanical factors increased the risk for disease progression. Moreover, inflammatory mediators, in particular, adipose tissue-derived cytokines (better known as adipokines) play a critical role linking obesity and osteoarthritis. The present article summarizes the knowledge about the role of adipokines in cartilage and bone function, highlighting their contribution to the imbalance of joint homeostasis and, consequently, pathogenesis of osteoarthritis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:594-604, 2018.
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