Show simple item record

dc.contributor.authorReal Peña, Eusebio 
dc.contributor.authorRevuelta Soba, José Manuel 
dc.contributor.authorGonzález Vargas, Nieves
dc.contributor.authorPontón Cortina, Alejandro 
dc.contributor.authorCalvo Díez, Marta
dc.contributor.authorLópez Higuera, José Miguel 
dc.contributor.authorConde Portilla, Olga María 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2018-03-13T15:27:07Z
dc.date.available2018-03-13T15:27:07Z
dc.date.issued2017
dc.identifier.issn0277-786X
dc.identifier.issn1996-756X
dc.identifier.otherFIS2010-19860es_ES
dc.identifier.otherTEC2016-76021-C2-2-Res_ES
dc.identifier.otherDTS15/00238es_ES
dc.identifier.urihttp://hdl.handle.net/10902/13293
dc.description.abstractDegenerative mitral regurgitation is a serious and frequent human heart valve disease. Malfunctioning of this valve brings the left-sided heart through a significant increase of pressure and volume overload. Severe degenerative mitral incompetence generally requires surgical repair or valve replacement with a bioprosthesis or mechanical heart valve. Degenerative disease affects the leaflets or/and the chordae tendineae, which link both leaflets to the papillary muscles. During mitral valve surgical repair, reconstruction of the valve leaflets, annulus and chordae are provided to prevent postoperative recurrence of valve regurgitation. The operative evaluation of the diseased and apparently normal chordae tendineae mainly depends of the surgeon´s experience, without any other objective diagnosis tool. In this work, PS-OCT (Polarization Sensitive-Optical Coherence Tomography) is applied for the first time to evaluate the pathological condition of human chordae coming from the mitral valve. It consists on a prospective study to test the viability of this technique for the evaluation of the collagen core of chords. This core presents a strong birefringence due to the longitudinal and organized arrangement of its collagen bundles. Different densities and organizations of the collagen core translate into different birefringence indicators whose measurement become an objective marker of the core structure. Ex-vivo mitral degenerative chordae tendineae have been analyzed with PS-OCT. Intensity OCT is used to obtain complementary morphological information of the chords. Birefringence results correlate with the previously reported values for human tendinous tissue.es_ES
dc.description.sponsorshipThe authors thank the “Ministerio de Economía, Industria y Competitividad” (MINECO) for their support in this work under projects DA2TOI (FIS2010-19860), SENSA (TEC2016-76021-C2-2-R), the “Instituto de Salud Carlos III” (ISCIII) through projects FUSIODERM (DTS15/00238) and CIBERBBN and the co-financed by FEDER funds.es_ES
dc.format.extent4 p.es_ES
dc.language.isoenges_ES
dc.publisherSPIE Society of Photo-Optical Instrumentation Engineerses_ES
dc.rightsCopyright 2017 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.es_ES
dc.sourceProceedings of SPIE, 2017, 10053, 1005334es_ES
dc.sourceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, San Francisco, 2017es_ES
dc.subject.otherPS-OCTes_ES
dc.subject.otherChordae tendineaees_ES
dc.subject.otherTendinous cordses_ES
dc.subject.otherCollagen organizationes_ES
dc.subject.otherBirrefringencees_ES
dc.subject.otherDegradation diagnosises_ES
dc.titleCollagen birefringence assessment in heart chordae tendineae through PS-OCTes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.relation.publisherVersionhttps://doi.org/10.1117/12.2254303es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1117/12.2254303
dc.type.versionpublishedVersiones_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record