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dc.contributor.authorSuberviola, Borjaes_ES
dc.contributor.authorRellan, Luzdivinaes_ES
dc.contributor.authorRiera, Jordies_ES
dc.contributor.authorIranzo, Reyeses_ES
dc.contributor.authorGarcía Campos, Ascensiónes_ES
dc.contributor.authorRobles, Juan Carloses_ES
dc.contributor.authorVicente, Rosarioes_ES
dc.contributor.authorMiñambres García, Eduardo es_ES
dc.contributor.authorSantibáñez Margüello, Miguel es_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractBackground Infections and primary graft dysfunction are devastating complications in the immediate postoperative period following lung transplantation. Nowadays, reliable diagnostic tools are not available. Biomarkers could improve early infection diagnosis. Methods Multicentre prospective observational study that included all centres authorized to perform lung transplantation in Spain. Lung infection and/or primary graft dysfunction presentation during study period (first postoperative week) was determined. Biomarkers were measured on ICU admission and daily till ICU discharge or for the following 6 consecutive postoperative days. Results We included 233 patients. Median PCT levels were significantly lower in patients with no infection than in patients with Infection on all follow up days. PCT levels were similar for PGD grades 1 and 2 and increased significantly in grade 3. CRP levels were similar in all groups, and no significant differences were observed at any study time point. In the absence of PGD grade 3, PCT levels above median (0.50 ng/ml on admission or 1.17 ng/ml on day 1) were significantly associated with more than two- and three-fold increase in the risk of infection (adjusted Odds Ratio 2.37, 95% confidence interval 1.06 to 5.30 and 3.44, 95% confidence interval 1.52 to 7.78, respectively). Conclusions In the absence of severe primary graft dysfunction, procalcitonin can be useful in detecting infections during the first postoperative week. PGD grade 3 significantly increases PCT levels and interferes with the capacity of PCT as a marker of infection. PCT was superior to CRP in the diagnosis of infection during the study period.es_ES
dc.format.extent13 p.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 4.0 Internacional*
dc.sourcePLoS One. 2017 Jul 13;12(7):e0180202es_ES
dc.titleRole of biomarkers in early infectious complications after lung transplantationes_ES

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Atribución 4.0 InternacionalExcept where otherwise noted, this item's license is described as Atribución 4.0 Internacional