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dc.contributor.authorIrure, Juanes_ES
dc.contributor.authorAsensio, Estheres_ES
dc.contributor.authorRodrigo Calabia, Emilio es_ES
dc.contributor.authorRomón Alonso, Íñigoes_ES
dc.contributor.authorGómez, Javieres_ES
dc.contributor.authorArias Rodríguez, Manuel es_ES
dc.contributor.authorLópez Hoyos, Marcos es_ES
dc.contributor.authorSan Segundo Arribas, Davides_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractThe definition of anti-HLA antibody profile in highly sensitized patients on a waiting list is crucial when virtual crossmatch is used in organ allocation systems, but also when used to identify the true deleterious anti-HLA antibodies. Here we propose different levels of risk based on the results of anti-HLA antibody testing in neat serum (N) and after sera dilution (DIL) and C1q test in 18 highly sensitized patients. This group was heterogeneous in terms of anti-HLA antibody titers and their ability to fix complement. After dilution, 15 out of 18 patients (83.3%) showed a reduction of positive bead counts whereas 4 patients showed a prozone effect and complement fixation was demonstrated. The high dilution of sera and ascertaining the complement fixation allow the accurate definition of risk anti-HLA antibody profiles in highly sensitized patients, as demonstrated in 5 of the sensitized patients who were transplanted.es_ES
dc.format.extent13 p.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 España*
dc.sourcePLoS One. 2017; 12(2): e0171463es_ES
dc.titleImprovement in the definition of anti-HLA antibody profile in highly sensitized patientses_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España