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dc.contributor.authorAlibi, Sanaes_ES
dc.contributor.authorFerjani, Asmaes_ES
dc.contributor.authorBoukadida, Jaleles_ES
dc.contributor.authorEliecer Cano, Maríaes_ES
dc.contributor.authorFernández Martínez, Martaes_ES
dc.contributor.authorMartínez Martínez, Luis es_ES
dc.contributor.authorNavas Méndez, Jesús es_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractCorynebacterium striatum is a nosocomial opportunistic pathogen increasingly associated with a wide range of human infections and is often resistant to several antibiotics. We investigated the susceptibility of 63 C. striatum isolated at the Farhat-Hached hospital, Sousse (Tunisia), during the period 2011?2014, to a panel of 16 compounds belonging to the main clinically relevant classes of antimicrobial agents. All strains were susceptible to vancomycin, linezolid, and daptomycin. Amikacin and gentamicin also showed good activity (MICs90 = 1 and 2 mg/L, respectively). High rates of resistance to penicillin (82.5%), clindamycin (79.4%), cefotaxime (60.3%), erythromycin (47.6%), ciprofloxacin (36.5%), moxifloxacin (34.9%), and rifampicin (25.4%) were observed. Fifty-nine (93.7%) out of the 63 isolates showed resistance to at least one compound and 31 (49.2%) were multidrug-resistant. Twenty-nine resistance profiles were distinguished among the 59 resistant C. striatum. Most of the strains resistant to fluoroquinolones showed a double mutation leading to an amino acid change in positions 87 and 91 in the quinolone resistance-determining region of the gyrA gene. The 52 strains resistant to penicillin were positive for the gene bla, encoding a class A ?-lactamase. Twenty-two PFGE patterns were identified among the 63 C. striatum, indicating that some clones have spread within the hospital.es_ES
dc.format.extent8 p.es_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAtribución 3.0 España*
dc.sourceSci. Rep. 2017 7, 9704es_ES
dc.titleOccurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospitales_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España