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    Conjugation Inhibitors and Their Potential Use to Prevent Dissemination of Antibiotic Resistance Genes in Bacteria

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    URI: http://hdl.handle.net/10902/12844
    DOI: 10.3389/fmicb.2017.02329
    ISSN: 1664-302X
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    Author
    Cabezón Navarro, María Elena; Cruz Calahorra, Fernando de la; Arechaga Iturregui, Ignacio María
    Date
    2017-11-30
    Abstract

    Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conjugation is one of the main mechanisms whereby bacteria become resistant to antibiotics. Therefore, the search for specific conjugation inhibitors (COINs) is of interest in the fight against the spread of antibiotic resistances in a variety of laboratory and natural environments. Several compounds, discovered as COINs, are promising candidates in the fight against plasmid dissemination. In this review, we survey the effectiveness and toxicity of the most relevant compounds. Particular emphasis has been placed on unsaturated fatty acid derivatives, as they have been shown to be efficient in preventing plasmid invasiveness in bacterial populations. Biochemical and structural studies have provided insights concerning their potential molecular targets and inhibitory mechanisms. These findings open a new avenue in the search of new and more effective synthetic inhibitors. In this pursuit, the use of structure-based drug design methods will be of great importance for the screening of ligands and binding sites of putative targets..

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    CC BY © Los autores. This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission
    Publicado en
    Frontiers in Microbiology November 2017 | Volume 8 | Article 2329
    Publisher
    Frontiers Research Foundation
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    • D55 Artículos [51]
    • D02 Artículos [159]

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    UNIVERSIDAD DE CANTABRIA

    Repositorio realizado por la Biblioteca Universitaria utilizando DSpace software
    Contact Us | Send Feedback
    Metadatos sujetos a:licencia de Creative Commons Reconocimiento 3.0 España