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dc.contributor.authorSailer, Annaes_ES
dc.contributor.authorScholz, Sonja W.es_ES
dc.contributor.authorNalls, Michael A.es_ES
dc.contributor.authorSchulte, Claudiaes_ES
dc.contributor.authorFederoff, Monicaes_ES
dc.contributor.authorPrice, T. Ryanes_ES
dc.contributor.authorLees, Andrewes_ES
dc.contributor.authorRoss, Owen A.es_ES
dc.contributor.authorDickson, Dennis W.es_ES
dc.contributor.authorMok, Kines_ES
dc.contributor.authorMencacci, Niccolo E.es_ES
dc.contributor.authorSchottlaender, Luciaes_ES
dc.contributor.authorChelban, Vioricaes_ES
dc.contributor.authorLing, Helenes_ES
dc.contributor.authorO´Sullivan, Sean S.es_ES
dc.contributor.authorWood, Nicholas W.es_ES
dc.contributor.authorTraynor, Bryan J.es_ES
dc.contributor.authorFerrucci, Luigies_ES
dc.contributor.authorFederoff, Howard J.es_ES
dc.contributor.authorInfante Ceberio, Jon es_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractObjective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with .5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed. Results: We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p , 1 3 1026, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA. Conclusions: We present a GWAS in MSA.We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps.es_ES
dc.format.extent8 p.es_ES
dc.publisherAmerican Academy of Neurologyes_ES
dc.rightsAtribución 3.0 España*
dc.sourceNeurology. 2016 Oct 11;87(15):1591-1598es_ES
dc.titleA genome-wide association study in multiple system atrophyes_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España