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dc.contributor.authorLópez Fanarraga, Mónica 
dc.contributor.authorCarranza Ferrer, Gerardo 
dc.contributor.authorCastaño Cobo, Raquel
dc.contributor.authorJiménez, Victoria 
dc.contributor.authorVillegas Sordo, Juan Carlos 
dc.contributor.authorZabala Otaño, Juan Carlos 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2012-12-10T10:46:13Z
dc.date.available2012-12-10T10:46:13Z
dc.date.issued2010-07
dc.identifier.issn1942-0889
dc.identifier.urihttp://hdl.handle.net/10902/1146
dc.description.abstractDespite its fundamental role in centrosome biology, procentriole formation both in the canonical and in the de novo replication pathways remains poorly understood, and the molecular components that are involved in human cells are not well established. We found that one of the tubulin cofactors, TBCD, is localized at centrosomes and the midbody, and is required for spindle organization, cell abscission, centriole formation, and ciliogenesis. Thus, we have established a molecular link between the centriole and the midbody, demonstrating that this cofactor is also necessary for microtubule retraction during cell abscission. TBCD is the first centriolar protein identified that plays a role in the assembly of both “centriolar rosettes” during early ciliogenesis, and at the procentriole budding site by S/G2, a discovery that directly implicates tubulin cofactors in the cell division, cell migration, and cell signaling research fields.es_ES
dc.format.extent9 p.es_ES
dc.language.isoenges_ES
dc.publisherLandes Biosciencees_ES
dc.rights(c) Landes Biosciencees_ES
dc.sourceCommunicative and Integrative Biology. 2010 Jul;3(4):306-8.es_ES
dc.subject.otherTBCses_ES
dc.subject.otherCofactorses_ES
dc.subject.otherTubulines_ES
dc.subject.otherFoldinges_ES
dc.subject.otherTBCDes_ES
dc.subject.otherCentrosomees_ES
dc.subject.otherCentrilogenesises_ES
dc.subject.otherCiliogenesis Abcissiones_ES
dc.titleEmerging roles for tubulin folding cofactors at the centrosomees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.4161/cib.3.4.11976
dc.type.versionacceptedVersiones_ES


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