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dc.contributor.authorGonçalves, João
dc.contributor.authorNolasco, Sofía
dc.contributor.authorNascimento, Rute
dc.contributor.authorLópez Fanarraga, Mónica 
dc.contributor.authorZabala Otaño, Juan Carlos 
dc.contributor.authorSoares, Helena
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2012-12-10T10:45:41Z
dc.date.available2012-12-10T10:45:41Z
dc.date.issued2010-03
dc.identifier.issn1469-221X
dc.identifier.urihttp://hdl.handle.net/10902/1145
dc.description.abstractIn animal cells the centrosome is actively positioned at the cell center in close association with the nucleus. The mechanisms responsible for this are not completely understood. Here we report the first characterization of human TBCCD1, a protein related to tubulin cofactor C. TBCCD1 localizes at the centrosome and at the spindle midzone, midbody and basal bodies of primary and motile cilia. Knockdown of TBCCD1 in RPE-1 cells caused the dissociation of the centrosome from the nucleus and disorganization of the Golgi apparatus. TBCCD1 depleted cells are larger, less efficient in primary cilia assembly and their migration is slower in wound-healing assays. However, the microtubule nucleating activity of the centrosome is not affected by TBCCD1 silencing. We propose that TBCCD1 is a key regulator of centrosome positioning and consequently of internal cell organization.es_ES
dc.format.extent21 p.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rights(c) European Molecular Biology Organization (EMBO)es_ES
dc.sourceEMBO Reports. 2010 Mar;11(3):194-200. Epub 2010 Feb 19.es_ES
dc.subject.otherCell migrationes_ES
dc.subject.otherCentrosomees_ES
dc.subject.otherGolgi apparatuses_ES
dc.subject.otherPrimary ciliaes_ES
dc.subject.otherTBCCD1es_ES
dc.titleTBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioninges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1038/embor.2010.5
dc.type.versionacceptedVersiones_ES


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