Tropheryma whipplei endocarditis in Spain Case reports of 17 prospective cases
EstadísticasView Usage Statistics
Full recordShow full item record
AuthorGarcía Álvarez, Lara; Sanz, María Mercedes; Marín, Mercedes; Fariñas Álvarez, María del Carmen; Armiñanzas Castillo, Carlos; Arnaiz García, Ana María; Berrazueta Fernández, José Ramón; Bellisco, Sara; Cobo Belaustegui, Manuel; Durán, Raquel; Fariñas Álvarez, María Concepción; Fernández Mazarrasa, Carlos; Gómez Izquierdo, Rubén; González Rico, Claudia; Gutiérrez Díez, José Francisco; Martín Durán, Rafael; Pajarón, Marcos; Parra Blanco, José Antonio; Teira Cobo, Ramón María; [et al.]
Tropheryma whipplei endocarditis is an uncommon condition with very few series and<90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on Endocarditis?Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España. From a total of 3165 cases included in the cohort, 14.2% were diagnosed of blood culture negative endocarditis (BCNE) and 3.5% of these had T. whipplei endocarditis. This condition was more frequent in men. The average age was 60.3 years. Previous cardiac condition was present in 35.3% of the cases. The main clinical manifestation was cardiac failure (76.5%) while fever was only present in the 35.3%. Ecocardiography showed vegetations in 64.7% of patients. Surgery was performed in all but 1 cases and it allowed the diagnosis when molecular assays were performed. A broad range rRNA 16S polymerase chain reaction was used for first instance in all laboratories and different specific targets for T. whipplei were employed for confirmation. A concomitant Whipple disease was diagnosed in 11.9% of patients. All patients received specific antimicrobial treatment for at least 1 year, with no relapse and complete recovery. T. whipplei endocarditis is an uncommon condition with an atypical presentation that must be considered in the diagnosis of BCNE. The prognosis is very good when an appropriate surgical management and antimicrobial-specific treatment is given.
Collections to which it belong
- D22 Artículos 
Showing items related by title, author, creator and subject.
Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. bacteremia. A multicentric cohort study Peralta Fernández, Francisco Galo; Lamelo Otero, María; Álvarez García, Patricia; Velasco Arribas, María; Delgado-Iribarren, Alberto; Horcajada Gallego, Juan Pablo; Montero, María Milagro; Roiz Mesones, María Pía; Fariñas Álvarez, María del Carmen; Alonso Gutiérrez, Juan; Martínez Martínez, Luis; Gutiérrez Macías, Alfonso; Álava Menica, José Ángel; Rodríguez Guardado, Azucena; Fleites, Ana; Navarro López, Vicente; Sirvent Quílez, Elia; Capdevila Morell, José Antonio (BioMed Central, 2012-10-05)