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dc.contributor.authorCastelló, Adelaes_ES
dc.contributor.authorBoldo, Elenaes_ES
dc.contributor.authorPérez Gómez, Beatrizes_ES
dc.contributor.authorLope, Virginiaes_ES
dc.contributor.authorAltzibar, Jone M.es_ES
dc.contributor.authorMartín, Vicentees_ES
dc.contributor.authorCastaño Vinyals, Gemmaes_ES
dc.contributor.authorGuevara, Marcelaes_ES
dc.contributor.authorDierssen Sotos, Trinidad es_ES
dc.contributor.authorTardón, Adoninaes_ES
dc.contributor.authorMoreno, Víctores_ES
dc.contributor.authorPuig Vives, Montserrates_ES
dc.contributor.authorLlorens Ivorra, Cristóbales_ES
dc.contributor.authorAlguacil Ojeda, Juanes_ES
dc.contributor.authorGómez Acebo, Inés es_ES
dc.contributor.authorCastilla, Jesúses_ES
dc.contributor.authorGracia Lavedán, Estheres_ES
dc.contributor.authorDávila Batista, Verónicaes_ES
dc.contributor.authorKogevinas, Manolises_ES
dc.contributor.authorAragonés, Nuriaes_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractObjective To externally validate the previously identified effect on breast cancer risk of the Western, Prudent and Mediterranean dietary patterns. Study design MCC-Spain is a multicase-control study that collected epidemiological information on 1181 incident cases of female breast cancer and 1682 control cases from 10 Spanish provinces. Three dietary patterns derived in another Spanish case-control study were analysed in the MCC-Spain study. These patterns were termed Western (high intakes of fatty and sugary products and red and processed meat), Prudent (high intakes of low-fat dairy products, vegetables, fruits, whole grains and juices) and Mediterranean (high intake of fish, vegetables, legumes, boiled potatoes, fruits, olives, and vegetable oil, and a low intake of juices). Their association with breast cancer was assessed using logistic regression models with random province-specific intercepts considering an interaction with menopausal status. Risk according to tumour subtypes ? based on oestrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors (ER+/PR+&HER2-; HER2+; ER-/PR-&HER2-) ? was evaluated with multinomial regression models. Main outcome measures Breast cancer and histological subtype. Results Our results confirm most of the associations found in the previous case-control study. A high adherence to the Western dietary pattern seems to increase breast cancer risk in both premenopausal women (OR4thvs.1stquartile(95%CI):1.68(1.02;2.79); OR1SD-increase(95%CI): 1.19(1.01;1.40)) and postmenopausal women (OR4thvs.1stquartile(95%CI):1.48(1.07;2.05); OR1SD-increase(95%CI): 1.14(1.01;1.28)). While high adherence to the Prudent pattern did not show any effect on breast cancer, the Mediterranean dietary pattern seemed to be protective, but only among postmenopausal women (OR4thvs.1stquartile (95%CI):0.72(95% CI 0.53;0.98); p-int = 0.075). There were no significant differences by tumour subtype. Conclusion Dietary recommendations based on a departure from the Western dietary pattern in favour of the Mediterranean diet could reduce breast cancer risk in the general population.es_ES
dc.description.sponsorshipThe study was funded by Carlos III Institute of Health grants (PI12/00488, PI12/00265, PI12/00715, PI12/01270, PI09/00773 and PI08/1770), by the Spanish Ministry of Economy and Competitiveness (IJCI-2014-20900) and by Consejería de Salud de la Junta de Andalucía (PI-0571- 2009 and PI-0306-2011) competitive calls including peer review for scientific quality. Additional funding was provided by the Spanish Federation of Breast Cancer Patients (FECMA: EPY 1169- 10), the Association of Women with Breast Cancer from Elche (AMACMEC:EPY 1394/15), the Marqués de Valdecilla foundation (grant API 10/09), ) and by Acción Transversal del Cancer, approved by the Spanish Ministry Council on October 11, 2007. None of the funders played any role in conducting research or writing the paper.es_ES
dc.format.extent29 p.es_ES
dc.publisherElsevier Science Publisherses_ES
dc.rights© <2017> Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 licensees_ES
dc.subject.otherMediterranean dietes_ES
dc.subject.otherWestern dietes_ES
dc.subject.otherBreast neoplasmses_ES
dc.subject.otherPrevention and controles_ES
dc.subject.otherPopulation attributable fractiones_ES
dc.titleAdherence to the Western, Prudent and Mediterranean dietary patterns and breast cancer risk: MCC-Spain studyes_ES

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© <2017> Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseExcept where otherwise noted, this item's license is described as © <2017> Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license