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dc.contributor.authorRúa Figueroa, Iñigoes_ES
dc.contributor.authorFernández de Castro, Mónicaes_ES
dc.contributor.authorAndreu, José L.es_ES
dc.contributor.authorSánchez Piedra, Carloses_ES
dc.contributor.authorMartínez Taboada, Víctor Manuel es_ES
dc.contributor.authorOlivé, Alejandroes_ES
dc.contributor.authorLópez Longo, Javieres_ES
dc.contributor.authorRosas, Josées_ES
dc.contributor.authorGalindo, Maríaes_ES
dc.contributor.authorCalvo Alén, Jaime es_ES
dc.contributor.authorFernández Nebro, Antonioes_ES
dc.contributor.authorAlonso, Fernando es_ES
dc.contributor.authorRodríguez Lozano, Beatrizes_ES
dc.contributor.authorGarcía Vadillo, Jesús Albertoes_ES
dc.contributor.authorMenor, Raúles_ES
dc.contributor.authorErausquin, Celiaes_ES
dc.contributor.authorGarcía Aparicio, Ángeles_ES
dc.contributor.authorTomero, Evaes_ES
dc.contributor.authorManrique Arija, Saraes_ES
dc.contributor.authorBlanco Alonso, Ricardoes_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2017-06-07T16:31:09Z
dc.date.available2017-06-07T16:31:09Z
dc.date.issued2016es_ES
dc.identifier.issn2151-464Xes_ES
dc.identifier.issn2151-4658es_ES
dc.identifier.urihttp://hdl.handle.net/10902/11171
dc.description.abstractOBJECTIVE: To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS: This was a cross-sectional multicenter study where the prevalence of more relevant comorbidities in 2 cohorts was compared. Patients under followup from SJOGRENSER (Spanish Rheumatology Society Registry of Primary SS) and RELESSER (Spanish Rheumatology Society Registry of SLE), and who fulfilled the 2002 American-European Consensus Group and 1997 American College of Rheumatology classification criteria, respectively, were included. A binomial logistic regression analysis was carried out to explore potential differences, making general adjustments for age, sex, and disease duration and specific adjustments for each variable, including CV risk factors and treatments, when appropriate. RESULTS: A total of 437 primary SS patients (95% female) and 2,926 SLE patients (89% female) were included. The mean age was 58.6 years (interquartile range [IQR] 50.0-69.9 years) for primary SS patients and 45.1 years (IQR 36.4-56.3 years) for SLE patients (P?<?0.001), and disease duration was 10.4 years (IQR 6.0-16.7 years) and 13.0 years (IQR 7.45-19.76 years), respectively (P?<?0.001). Smoking, dyslipidemia, and arterial hypertension were associated less frequently with primary SS (odds ratio [OR] 0.36 [95% confidence interval (95% CI) 0.28-0.48], 0.74 [95% CI 0.58-0.94], and 0.50 [95% CI 0.38-0.66], respectively) as were life-threatening CV events (i.e., stroke or myocardial infarction; OR 0.57 [95% CI 0.35-0.92]). Conversely, lymphoma was associated more frequently with primary SS (OR 4.41 [95% CI 1.35-14.43]). The prevalence of severe infection was lower in primary SS than in SLE (10.1% versus 16.9%; OR 0.54 [95% CI 0.39-0.76]; P?<?0.001). CONCLUSION: Primary SS patients have a consistently less serious CV comorbidity burden and a lower prevalence of severe infection than those with SLE. In contrast, their risk of lymphoma is greater.es_ES
dc.format.extent32 p.es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.rights© American College of Rheumatolog. Published by John Wiley & Sons. This is the peer reviewed version of the following article: Rúa-Figueroa, I., Fernández Castro, M., Andreu, J. L., Sanchez-Piedra, C., Martínez-Taboada, V., Olivé, A., López-Longo, J., Rosas, J., Galindo, M., Calvo-Alén, J., Fernández-Nebro, A., Alonso, F., Rodríguez-Lozano, B., Alberto García Vadillo, J., Menor, R., Narváez, F. J., Erausquin, C., García-Aparicio, Á., Tomero, E., Manrique-Arija, S., Horcada, L., Uriarte, E., Gil, S., Blanco, R., López-González, R., Boteanu, A., Freire, M., Galisteo, C., Rodríguez-Gómez, M., Díez-Álvarez, E., Pego-Reigosa, J. M. and on behalf of Sjogrenser and Relesser Researchers and EAS-SER Group (2017), Comorbidities in Patients With Primary Sjögren's Syndrome and Systemic Lupus Erythematosus: A Comparative Registries-Based Study. Arthritis Care & Research, 69: 38-45, which has been published in final form at doi:10.1002/acr.23015. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.es_ES
dc.sourceArthritis Care Res (Hoboken). 2017 Jan;69(1):38-45es_ES
dc.titleComorbidities in patients with Primary Sjögren's Syndrome and Systemic Lupus Erythematosus: A comparative registries-based studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.DOI10.1002/acr.23015es_ES
dc.type.versionacceptedVersiones_ES


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