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dc.contributor.authorDelgado-González, José Carlos
dc.contributor.authorMansilla-Legorburo, Francisco
dc.contributor.authorFlorensa-Vila, José
dc.contributor.authorInsausti, Ana María
dc.contributor.authorViñuela, Antonio
dc.contributor.authorTuñón-Álvarez, Teresa
dc.contributor.authorCruz Rodríguez, Marcos 
dc.contributor.authorMohedano-Moriano, Alicia
dc.contributor.authorInsausti, Ricardo
dc.contributor.authorArtacho-Pérula, Emilio
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.description.abstractThe decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures and their quantitative estimate in microscopic examination. Twelve control cases had ex-vivo MRI, and thereafter, the temporal lobe of both hemispheres was sectioned from the pole as far as the level of the splenium of the corpus callosum. Nissl stain was used to establish anatomical boundaries between structures in the medial temporal lobe. The study included morphometrical and stereological estimates of the amygdaloid complex, hippocampus, and temporal horn of the lateral ventricle, as well as different regions of grey and white matter in the temporal lobe. Data showed a close association between morphometric MRI images values and those based on the histological determination of boundaries. Only values in perimeter and circularity of the piamater were different. This correspondence is also revealed by the stereological study, although irregular compartments resulted in a lesser agreement. Neither age (< 65 yr and > 65yr) nor hemisphere had any effect. Our results indicate that ex-vivo MRI is highly associated with quantitative information gathered by histological examination, and these data could be used as structural MRI biomarker in neurodegenerative diseases.es_ES
dc.description.sponsorshipEAP and RI acknowledge financial support from the Spanish Ministry of Science and Innovation I+D+i Project BFU-2009-14705, and from the Education, Culture and Sports of Castilla-La Mancha Autonomic Government Project PPII-2014-013-A.es_ES
dc.format.extent16 p.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.titleQuantitative Measurements in the Human Hippocampus and Related Areas: Correspondence between Ex-Vivo MRI and Histological Preparationses_ES

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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España