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dc.contributor.authorVillar Ramos, Ana Victoria 
dc.contributor.authorCobo Belaustegui, Manuel
dc.contributor.authorLlano Cardenal, Miguel
dc.contributor.authorMontalvo Silva, Cecilia de
dc.contributor.authorGonzález-Vílchez, Francisco
dc.contributor.authorMartín Durán, Rafael 
dc.contributor.authorHurlé González, María Amor 
dc.contributor.authorNistal Herrera, Juan Francisco 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2012-11-26T11:33:17Z
dc.date.available2012-11-26T11:33:17Z
dc.date.issued2009-12-30
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10902/1021
dc.description.abstractBackground: TGF-b1 is involved in cardiac remodeling through an auto/paracrine mechanism. The contribution of TGF-b1 from plasmatic source to pressure overload myocardial remodeling has not been analyzed. We investigated, in patients with valvular aortic stenosis (AS), and in mice subjected to transverse aortic arch constriction (TAC), whether plasma TGF-b1 relates with myocardial remodeling, reflected by LV transcriptional adaptations of genes linked to myocardial hypertrophy and fibrosis, and by heart morphology and function. Methodology/Principal Findings: The subjects of the study were: 39 patients operated of AS; 27 healthy volunteers; 12 mice subjected to TAC; and 6 mice sham-operated. Myocardial samples were subjected to quantitative PCR. Plasma TGF-b1 was determined by ELISA. Under pressure overload, TGF-b1 plasma levels were significantly increased both in AS patients and TAC mice. In AS patients, plasma TGF-b1 correlated directly with aortic transvalvular gradients and LV mass surrogate variables, both preoperatively and 1 year after surgery. Plasma TGF-b1 correlated positively with the myocardial expression of genes encoding extracellular matrix (collagens I and III, fibronectin) and sarcomeric (myosin light chain-2, b-myosin heavy chain) remodelling targets of TGF-b1, in TAC mice and in AS patients. Conclusions/Significance: A circulating TGF-b1-mediated mechanism is involved, in both mice and humans, in the excessive deposition of ECM elements and hypertrophic growth of cardiomyocytes under pressure overload. The possible value of plasma TGF-b1 as a marker reflecting preoperative myocardial remodeling status in AS patients deserves further analysis in larger patient cohorts.es_ES
dc.format.extent8 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourcePLoS One. 2009 Dec 30;4(12):e8476.es_ES
dc.titlePlasma levels of transforming growth factor-beta1 reflect left ventricular remodeling in aortic stenosises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1371/journal.pone.0008476
dc.type.versionpublishedVersiones_ES


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Atribución 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución 3.0 España