Mostrar el registro sencillo

dc.contributor.authorGil Gómez, Amparo es_ES
dc.contributor.authorGonzález-Vélez, Virginiaes_ES
dc.contributor.authorSegura Sala, José Javier es_ES
dc.contributor.authorGutiérrez, Luis Migueles_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2016-02-12T11:55:15Z
dc.date.available2016-02-12T11:55:15Z
dc.date.issued2014es_ES
dc.identifier.issn1547-1063es_ES
dc.identifier.issn1551-0018es_ES
dc.identifier.urihttp://hdl.handle.net/10902/8045
dc.description.abstractA theoretical analysis of some of the relevant factors influencing the calcium time course and the strength and timing of release probabilities of vesicles evoked by an action potential in a calyx-type active zone is presented in this paper. In particular, our study focus on the comparison of cooperative vs non-cooperative calcium binding by the release site and the effect of the number of Ca2+ binding sites on the calcium sensitivity for release. Regarding the comparison of cooperative and non-cooperative kinetic schemes, our simulations show that quite different results are obtained when considering one or another: a reduction in the release probability of more than a 50% is obtained when considering the cooperative kinetic scheme. Also, a delay in the average time for release appears when using this model for the calcium sensor. Our study also shows that a non-cooperative kinetic binding scheme gives rise to a well defined average calcium level for release assuming that the same kinetic constants are considered for all the sites. Our results also suggest that the central value of the calcium sensitivity for release depends on the number of binding sites N and the dissociation constant KD with a scaling law depending on NKD.es_ES
dc.language.isoenges_ES
dc.publisherArizona State Universityes_ES
dc.rights© American Institute of Mathematical Sciences. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Mathematical Biosciences and Engineering following peer review. The definitive publisher-authenticated version Mathematical Biosciences and Engineering Volume 11, Number 5, October 2014, pp. 1027-1043 is available online at: https://aimsciences.org/journals/displayArticlesnew.jsp?paperID=9996es_ES
dc.sourceMathematical Biosciences and Engineering Volume 11, Number 5, October 2014, pp. 1027-1043es_ES
dc.titleA theoretical study of factors influencing calcium-secretion coupling in a presynaptic active zone modeles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://aimsciences.org/journals/displayArticlesnew.jsp?paperID=9996es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.3934/mbe.2014.11.1027es_ES
dc.type.versionacceptedVersiones_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo