Analysis of thermal effects in endoscopic nanocarriers-based photodynamic therapy applied to esophageal diseases

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URI: http://hdl.handle.net/10902/7973
ISSN: 1996-756X
ISSN: 0277-786X
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Autoría
Salas García, IreneAutoridad Unican; Fanjul Vélez, FélixAutoridad Unican; Ortega Quijano, NoéAutoridad Unican; Wilfert, O.; Hudcova, L.; Poliak, Juraj; Barcik, J.; Arce Diego, José LuisAutoridad Unican
Fecha
2014
Derechos
© 2014 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Publicado en
Proceedings of SPIE, 2014, vol. 8941, 89410C
Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications, San Francisco, 2014
Editorial
SPIE Society of Photo-Optical Instrumentation Engineers
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Palabras clave
Esophageal tumor
Photodynamic therapy
Gold nanoparticles
Photo-thermal interaction
Endoscopic PDT
Resumen/Abstract
In this work we propose a predictive model that allows the study of thermal effects produced when the optical radiation interacts with an esophageal or stomach disease with gold nanoparticles embedded. The model takes into account light distribution in the tumor tissue by means of a Monte Carlo method. Mie theory is used to obtain the gold nanoparticles optical properties and the thermal model employed is based on the bio-heat equation. The complete model was applied to two types of tumoral tissue (squamous cell carcinoma located in the esophagus and adenocarcinoma in the stomach) in order to study the thermal effects induced by the inclusion of gold nanoparticles.
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