Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes

García Hevia, Lorena; Valiente Barroso, Rafael; Fernández Luna, José Luis; Flahaut, Emanuel; Rodríguez Fernández, Lidia; Villegas Sordo, Juan Carlos; González Gómez, Jesús Antonio; López Fanarraga, Mónica

doi:10.1002/adhm.201500252

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Identificadores

URI: http://hdl.handle.net/10902/7930

DOI: 10.1002/adhm.201500252

ISSN: 2192-2640

Fecha

2015-08-05

Derechos

© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: García-Hevia, L., Valiente, R., Fernández-Luna, J. L., Flahaut, E., Rodríguez-Fernández, L., Villegas, J. C., González, J. and Fanarraga, M. L. (2015), Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes. Advanced Healthcare Materials, 4: 1640–1644. doi: 10.1002/adhm.201500252, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/adhm.201500252/abstract

Publicado en

Advanced Healthcare Materials . 2015 Aug 5;4(11):1640-4

Editorial

Wiley

Enlace a la publicación

http://onlinelibrary.wiley.com/doi/10.1002/adhm.201500252/abstract

Palabras clave

Biomechanics

Cancer

Cytoskeleton

Metastasis

Tubulin polymers

Resumen/Abstract

Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.