Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy

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URI: http://hdl.handle.net/10902/4584
ISSN: 1539-4794
ISSN: 0146-9592
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Autoría
Salas García, IreneAutoridad Unican; Fanjul Vélez, FélixAutoridad Unican; Arce Diego, José LuisAutoridad Unican
Fecha
2014-04-01
Derechos
© 2014 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.39.001845. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
Publicado en
Optics Letters, 2014, 39(7), 1845-1848
Editorial
The Optical Society (OSA)
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Palabras clave
Photodynamic therapy
Light propagation in tissues
Fluorescence
Photochemistry
Resumen/Abstract
Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.
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