Innate immnunity on Antiphospholipid Syndrome : TLRs implication on imflammation

Abstract

The main aim of this study is to evaluate the function of the TLRs and the expression levels of the genes involved in the TLR pathway on blood mononuclear cell populations from healthy controls and patients suffering of different subtypes of antiphospholipid syndrome, and then to be able to relate those results with APS different clinical manifestations: Primary APS with vascular thrombosis, Primary APS with obstetric complications, Secondary APS, and Seropositive patients with no clinical manifestation. In case to confirm that this relation exists, we could really be sure that the innate immune responses have something to do with APS manifestation, and its molecular mechanisms would be closer to be known and better explained, which is really important for treatment development.