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SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients

dc.contributor.authorGarcía Bermúdez, Mercedes
dc.contributor.authorLópez Mejías, Raquel
dc.contributor.authorGenre, Fernanda
dc.contributor.authorCastañeda Sanz, Santos
dc.contributor.authorGonzález Juanatey, Carlos
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.authorCorrales Martínez, Alfonso
dc.contributor.authorMiranda Filloy, José Alberto
dc.contributor.authorRueda Gotor, Javier
dc.contributor.authorGómez Vaquero, Carmen
dc.contributor.authorRodríguez Rodríguez, Luis
dc.contributor.authorFernández Gutiérrez, Benjamín
dc.contributor.authorPascual Salcedo, Dora
dc.contributor.authorBalsa Criado, Alejandro
dc.contributor.authorLópez Longo, Francisco J.
dc.contributor.authorCarreira Delgado, Patricia
dc.contributor.authorBlanco Alonso, Ricardo 
dc.contributor.authorGonzález Álvaro, Isidoro
dc.contributor.authorMartín Ibáñez, Javier
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2013-12-16T12:23:37Z
dc.date.available2013-12-16T12:23:37Z
dc.date.issued2013-10-21
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10902/4048
dc.description.abstractRheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. Previous genome-wide association studies have described SMAD3 rs17228212 polymorphism as an important signal associated with CV events. The aim of the present study was to evaluate for the first time the relationship between this gene polymorphism and the susceptibility to CV manifestations and its potential association with the presence of subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in patients with RA.es_ES
dc.description.sponsorshipThis study was supported by grants from “Fondo de Investigaciones Sanitarias” PS09/00748 and PI12/00060 (Spain). This work was also partially supported by RETICS Program (RIER) RD12/0009/0013 and RD12/0009/0004 from “Instituto de Salud Carlos III” (ISCIII) (Spain). This work was supported in part by grants from the European IMI BTCure Program. MGB is a beneficiary of a grant from Fundación Española de Reumatología (FER). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain). FG is supported by funds from the RETICS Program (RIER). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.extent7 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourcePLoS One, 2013, 8(10), e77695es_ES
dc.titleSMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1371/journal.pone.0077695
dc.type.versionpublishedVersiones_ES


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