SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients

García Bermúdez, Mercedes; López Mejías, Raquel; Genre, Fernanda; Castañeda Sanz, Santos; González Juanatey, Carlos; Llorca Díaz, Francisco Javier; Corrales Martínez, Alfonso; Miranda Filloy, José Alberto; Rueda Gotor, Javier; Gómez Vaquero, Carmen; Rodríguez Rodríguez, Luis; Fernández Gutiérrez, Benjamín; Pascual Salcedo, Dora; Balsa Criado, Alejandro; López Longo, Francisco J.; Carreira Delgado, Patricia; Blanco Alonso, Ricardo; González Álvaro, Isidoro; Martín Ibáñez, Javier; González-Gay Mantecón, Miguel Ángel

doi:10.1371/journal.pone.0077695

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Identificadores

URI: http://hdl.handle.net/10902/4048

DOI: 10.1371/journal.pone.0077695

ISSN: 1932-6203

Fecha

2013-10-21

Derechos

Attribution 4.0 International

Publicado en

PLoS One, 2013, 8(10), e77695

Editorial

Public Library of Science

Resumen/Abstract

Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. Previous genome-wide association studies have described SMAD3 rs17228212 polymorphism as an important signal associated with CV events. The aim of the present study was to evaluate for the first time the relationship between this gene polymorphism and the susceptibility to CV manifestations and its potential association with the presence of subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in patients with RA.

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