Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis

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URI: https://hdl.handle.net/10902/38908
ISSN: 0165-1781
ISSN: 1872-7123
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Autoría
Pelayo Terán, José María; Pérez Iglesias, Rocio; Vázquez Bourgon, JavierAutoridad Unican; Mata Pastor, Ignacio; Carrasco Marín, Eugenio; Vázquez Barquero, José LuisAutoridad Unican; Crespo Facorro, BenedictoAutoridad Unican
Fecha
2011-01-30
Derechos
Alojado según Resolución CNEAI 10/12/25 (ANECA) © 2010 Elsevier Ireland Ltd. All rights reserved.
Publicado en
Psychiatry Research, 2011, 185(1-2), 286-289
Editorial
Elsevier
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Palabras clave
COMT Val158Met
Antipsychotic response
First episode psychosis
Psychosis
Neuroimaging-genetics
Resumen/Abstract
Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.
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