Cajal's contribution to the knowledge of the neuronal cell nucleus
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Lafarga Coscojuela, Miguel Ángel
; Berciano Blanco, María Teresa
; Oriol Narcís, J.; Baltanás, Fernando C.; Tapia, Olga
Fecha
2005Derechos
© 2025 Lafarga, Berciano, Narcís, Baltanás and Tapia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Publicado en
Frontiers in Neuroanatomy, 2005, 19, 1724830
Editorial
Frontiers Media S.A.
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Resumen/Abstract
In 1906, Cajal was awarded the Nobel Prize in Physiology or Medicine for his pioneering studies on the structure and organization of nerve centers. Notably, in 1910, Cajal published a seminal work in which he described the essential components of the neuronal nucleus, primarily using his reduced silver nitrate procedure. Using modern microscopy techniques, we have identified the current equivalents of the structures originally described by Cajal. These include the fibrillar centerdense fibrillar component units? of the nucleolus, nuclear speckles, transcription factories, and the Cajal body. Importantly, these structures represent key nuclear compartments involved in the transcription of rDNA and protein-coding genes, pre-rRNA and pre-mRNA processing and spatial genome organization. Most of the nuclear components described by Cajal are now recognized as dynamic ?nuclear condensates assembled through liquid?liquid phase separation mechanisms that depend on various categories of RNA and RNA-binding proteins.
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